Affordable Access

deepdyve-link
Publisher Website

Chinese herbal medicine for obesity: a randomized, double-blinded, multicenter, prospective trial.

Authors
  • Zhou, Qiang
  • Chang, Bai
  • Chen, Xin-Yan
  • Zhou, Shui-Ping
  • Zhen, Zhong
  • Zhang, Lan-Lan
  • Sun, Xin
  • Zhou, Yuan
  • Xie, Wan-Qing
  • Liu, Hong-Fang
  • Xu, Yuan
  • Kong, Yi
  • Zhou, Li-Bo
  • Lian, Feng-Mei
  • Tong, Xiao-Lin
Type
Published Article
Journal
The American journal of Chinese medicine
Publication Date
Jan 01, 2014
Volume
42
Issue
6
Pages
1345–1356
Identifiers
DOI: 10.1142/S0192415X14500840
PMID: 25406653
Source
Medline
Keywords
License
Unknown

Abstract

Obesity is a serious medical problem worldwide. As a holistic therapy, traditional Chinese medicine (TCM) may have a potential in obesity management. In this controlled trial, we evaluated the safety and effectiveness of xin-ju-xiao-gao-fang (XJXGF), a TCM herbal formulation, in 140 obese subjects over a 24-week period. The XJXGF formula mainly consists of rhubarb, coptis, semen cassia, and citrus aurantium. Subjects with body mass index (BMI) 28-40 kg/m(2) were recruited at 5 centers in China. We assessed the changes in subjects' body weight, its related parameters, and the reduction of insulin resistance (IR) after administration of XJXGF formula or low-dose XJXGF (10% of the XJXGF formula, as control). After 24-week treatment, among participants in the XJXGF formula group and low-dose XJXGF group, the mean ± SE changes in the body weight were -3.58 ± 0.48 and -1.91 ± 0.38 kg, respectively (p < 0.01). The changes in the IR-index of two groups were -2.65 ± 1.04 and -1.58 ± 1.3, respectively (p < 0 .05). There were no serious adverse events reported during the 24-week trial. Participants reported 7 minor adverse events, 4 in the XJXGF formula group and 3 in the low-dose XJXGF group (p = 0.578). Future studies are needed to investigate the clinical utility of this TCM formulation in the treatment of obese subjects.

Report this publication

Statistics

Seen <100 times