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Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.

Authors
  • Bendor, Cole D1, 2
  • Bardugo, Aya1, 2
  • Zucker, Inbar3, 4
  • Cukierman-Yaffe, Tali3, 5
  • Lutski, Miri4
  • Derazne, Estela3
  • Shohat, Tammy3, 4
  • Mosenzon, Ofri6
  • Tzur, Dorit1, 2
  • Sapir, Ari1, 2
  • Pinhas-Hamiel, Orit3, 7
  • Kibbey, Richard G8, 9
  • Raz, Itamar6
  • Afek, Arnon3, 10
  • Gerstein, Hertzel C11
  • Tirosh, Amir3, 5
  • Twig, Gilad12, 2, 3, 5
  • 1 Department of Military Medicine, Hebrew University, Jerusalem, Israel. , (Israel)
  • 2 Israel Defense Forces Medical Corps, Ramat Gan, Israel. , (Israel)
  • 3 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. , (Israel)
  • 4 Ministry of Health, Israel Center for Disease Control, Ramat Gan, Israel. , (Israel)
  • 5 Institute of Endocrinology, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel. , (Israel)
  • 6 The Diabetes Unit, Division of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel. , (Israel)
  • 7 Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel. , (Israel)
  • 8 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.
  • 9 Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT.
  • 10 Central Management, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel. , (Israel)
  • 11 Department of Medicine, McMaster University, Hamilton, Ontario, Canada. , (Canada)
  • 12 Department of Military Medicine, Hebrew University, Jerusalem, Israel [email protected] , (Israel)
Type
Published Article
Journal
Diabetes care
Publication Date
Jan 01, 2020
Volume
43
Issue
1
Pages
145–151
Identifiers
DOI: 10.2337/dc19-1562
PMID: 31694859
Source
Medline
Language
English
License
Unknown

Abstract

The relationship between acute pancreatitis and incident diabetes is unclear. We assessed whether a resolved single event of acute pancreatitis in childhood was associated with incident diabetes in adulthood. A nationwide, population-based study of 1,802,110 Israeli adolescents (mean age 17.4 years [range 16-20]) who were examined before compulsory military service between 1979 and 2008 and whose data were linked to the Israeli National Diabetes Registry (INDR). Resolved pancreatitis was defined as a history of a single event of acute pancreatitis with normal pancreatic function at enrollment. Logistic regression analysis was applied. Incident diabetes developed in 4.6% of subjects with resolved pancreatitis (13 of 281; none of these cases were identified as type 1 diabetes) and 2.5% among the unexposed group (44,463 of 1,801,716). Resolved acute pancreatitis was associated with incident diabetes with an odds ratio (OR) of 2.23 (95% CI 1.25-3.98) with adjustment for age, sex, and birth year. Findings persisted after further adjustments for baseline BMI and sociodemographic confounders (OR 2.10 [95% CI 1.15-3.84]). Childhood pancreatitis was associated with a diagnosis of diabetes at a younger age, with 92% of diabetes case subjects diagnosed before 40 years of age compared with 47% in the unexposed group (P = 0.002). The association accentuated when the study sample was limited to individuals of unimpaired health or normal BMI at baseline. A history of acute pancreatitis in childhood with normal pancreatic function in late adolescence is a risk factor for incident type 2 diabetes, especially at young adulthood. © 2019 by the American Diabetes Association.

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