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Cherenkov imaging for Total Skin Electron Therapy – an evaluation of dose uniformity

Authors
  • Zhu, Timothy C.1
  • Ong, Yihong1
  • Sun, Hongjin1
  • Zhong, Weili1
  • Miao, Tianshun2
  • Dimofte, Andreea1
  • Bruza, Petr2
  • Maity, Amit1
  • Plastaras, John P.1
  • Paydar, Ima1
  • Dong, Lei1
  • Pogue, Brian W.2
  • 1 Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104;
  • 2 Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Type
Published Article
Journal
Proceedings of SPIE--the International Society for Optical Engineering
Publication Date
Mar 30, 2021
Volume
11628
Identifiers
DOI: 10.1117/12.2583939
PMID: 34083857
PMCID: PMC8171222
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Total Skin Electron Therapy (TSET) utilizes high-energy electrons to treat cancers on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high-energy electron beam and tissue. Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real-time using a time-gated intensified camera system. Each patient was monitored during TSET by in-vivo detectors (IVD) as well as Scintillators. Patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. A rigorous methodology for converting Cherenkov intensity to surface dose as products of correction factors, including camera vignette correction factor, incident radiation correction factor, and tissue optical properties correction factor. A comprehensive study has been carried out by inspecting various positions on the patients such as vertex, chest, perineum, shins, and foot relative to the umbilicus point (the prescription point).

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