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Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the (pro)renin receptor.

Authors
  • Greco, Carolina M
  • Camera, Marina
  • Facchinetti, Laura
  • Brambilla, Marta
  • Pellegrino, Sara
  • Gelmi, Maria Luisa
  • Tremoli, Elena
  • Corsini, Alberto
  • Ferri, Nicola
Type
Published Article
Journal
Cardiovascular Research
Publisher
Oxford University Press
Publication Date
Aug 01, 2012
Volume
95
Issue
3
Pages
366–374
Identifiers
DOI: 10.1093/cvr/cvs204
PMID: 22721990
Source
Medline
License
Unknown

Abstract

These results demonstrate that prorenin is a chemotactic factor for human aortic SMCs expressing PRR. This effect is elicited through reorganization of the cytoskeleton and focal adhesion, activation of RhoA and Rac1, and calpain-mediated cleavage of pp125(FAK).

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