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Chemosensors in the nose: guardians of the airways.

Authors
  • Tizzano, Marco
  • Finger, Thomas E
Type
Published Article
Journal
Physiology (Bethesda, Md.)
Publication Date
Jan 01, 2013
Volume
28
Issue
1
Pages
51–60
Identifiers
DOI: 10.1152/physiol.00035.2012
PMID: 23280357
Source
Medline
License
Unknown

Abstract

The G-protein-coupled receptor molecules and downstream effectors that are used by taste buds to detect sweet, bitter, and savory tastes are also utilized by chemoresponsive cells of the airways to detect irritants. Here, we describe the different cell types in the airways that utilize taste-receptor signaling to trigger protective epithelial and neural responses to potentially dangerous toxins and bacterial infection.

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