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The Chemistry behind ThiC Rearrangement.

Authors
  • Sun, Ying-Jie1, 2
  • Cheng, Liang1, 2
  • 1 Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. , (China)
  • 2 University of Chinese Academy of Sciences, Beijing, 100049, P. R. China. , (China)
Type
Published Article
Journal
ChemBioChem
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 05, 2022
Volume
23
Issue
1
Identifiers
DOI: 10.1002/cbic.202100385
PMID: 34494352
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Thiamine (vitamin B1) is crucial for life and plays a central role in metabolism. It contains thiazole and pyrimidine moieties that are constructed independently and then assembled together to generate thiamine phosphate. The study of the thiazole moiety is relatively clear, but deciphering the mechanistic enzymology of thiamine pyrimidine is more difficult. This review aims to summarize the recent research progress on ThiC rearrangement, mainly including the mechanism, related enzymes, and genes involved in the rearrangement. © 2021 Wiley-VCH GmbH.

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