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Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer.

Authors
  • Huus, Kasper
  • Havelund, Svend
  • Olsen, Helle B
  • van de Weert, Marco
  • Frokjaer, Sven
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Nov 01, 2006
Volume
23
Issue
11
Pages
2611–2620
Identifiers
PMID: 16969698
Source
Medline
License
Unknown

Abstract

Thermal stability can be used to predict the rate of Asn(B3) deamidation in human insulin. Chemical degradation processes that do not rely on the structural stability of the protein do not necessarily correlate to the thermal stability.

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