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Chemical constituents and biological activities of the genus Linaria (Scrophulariaceae).

Authors
  • Cheriet, Thamere
  • Mancini, Ines
  • Seghiri, Ramdane
  • Benayache, Fadila
  • Benayache, Samir
Type
Published Article
Journal
Natural product research
Publication Date
Jan 01, 2015
Volume
29
Issue
17
Pages
1589–1613
Identifiers
DOI: 10.1080/14786419.2014.999243
PMID: 25674928
Source
Medline
Keywords
License
Unknown

Abstract

This is a review on 95 references dealing with the genus Linaria (Scrophularioideae-Antirrhineae tribe), a known genus of the Scrophulariaceae family, which comprises about 200 species mainly distributed in Europe, Asia and North Africa. The use of some Linaria species in folk medicine has attracted the attention for chemical and biological studies. This report is aimed to be a comprehensive overview on the isolated or identified known and often new metabolites from the 41 Linaria species so far cited. It is organised presenting first the phytochemical classes of alkaloids, polyphenols including flavonoids, the latter being quite diffused and mostly present as flavones, flavonols and their glycosides, and terpenoids including iridoids and steroids. Second, the results from biological investigation on plant extracts, pure natural products isolated from Linaria species and some synthetic derivatives are reported, with antitumour, anti-acetylcholinesterase, anti-inflammatory and analgesic, antioxidant and antibacterial activities.

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