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Chemical constituents with antimicrobial and antioxidant activity from the aerial parts of Callistemon lanceolatus (Sm.) Sweet.

Authors
  • Nazreen, Syed1, 2
  • Mahboob Alam, Mohammad1, 2
  • Hamid, Hinna2
  • Ali, Mohammad3
  • Sarwar Alam, Mohammad2
  • 1 Faculty of Science, Department of Chemistry, Al Baha University, Kingdom of Saudi Arabia. , (Saudi Arabia)
  • 2 Faculty of Science, Department of Chemistry, Jamia Hamdard (Hamdard University), New Delhi, India. , (India)
  • 3 Faculty of Pharmacy, Department of Pharmacognosy and Phytochemistry, Jamia Hamdard (Hamdard University), New Delhi, India. , (India)
Type
Published Article
Journal
Natural product research
Publication Date
Nov 01, 2020
Volume
34
Issue
22
Pages
3275–3279
Identifiers
DOI: 10.1080/14786419.2018.1557174
PMID: 30618279
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Callistemon lanceolatus (Sm.) Sweet grows all over the world and used to treat cough and bronchitis. The air-dried powder of the aerial parts was exhaustively extracted with methanol and the concentrated extract was adsorbed on silica gel for preparation of slurry. It was dried and subjected to silica gel column packed in petroleum ether. The column was eluted with organic solvents in order of increasing polarity to isolate 1-triacosanol (1), n-eicosanyl palmitate (2), n-heptadecanyl arachidate (3), n-tricosanyl palmitate, (4), 4-hydroxyphenethyl carbocerate (5), 4-hydroxyphenethyl gheddate (6), urs-12-en-3α-acetoxy-18β-H-28-oic acid (7) and stigmast-5-en-3β-ol-3β-D-glucuronopyranoside (8). Among them, compound 5 and 6 were new fatty acid ester isolated from this plant. Compound 7 showed MIC 32 µg/mL against E. coli which was comparable to amoxicillin having same MIC 32 µg/mL. Compound 5 and 6 showed significant antioxidant activity by inhibiting DPPH due to the presence of phenolic groups.

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