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Checkpoints in the cell cycle from a modeler's perspective.

Authors
  • Tyson, J J
  • Novak, B
  • Chen, K
  • Val, J
Type
Published Article
Journal
Progress in cell cycle research
Publication Date
Jan 01, 1995
Volume
1
Pages
1–8
Identifiers
PMID: 9552349
Source
Medline
License
Unknown

Abstract

The cell division cycle is a complex process by which cells grow and divide into two viable daughter cells. So that mistakes are not made in this crucial replication process, cells stop at one or more "checkpoints" in the cycle to query their internal state and external conditions, before proceeding to the next stage of the cycle. In this paper we study some simple mathematical models of cell cycle arrest in G1 ("Start") and G2. Our models help to relate the molecular mechanisms of these checkpoints with physiological properties of the cell cycle.

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