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Checkpoint Responses to DNA Double-Strand Breaks

Authors
  • Waterman, David P.
  • Haber, James E.
  • Smolka, Marcus B.
Type
Published Article
Journal
Annual Review of Biochemistry
Publisher
Annual Reviews
Publication Date
Jun 20, 2020
Volume
89
Pages
103–133
Identifiers
DOI: 10.1146/annurev-biochem-011520-104722
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.

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