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Characterizing the molecular epidemiology of anaesthesia work area transmission of Staphylococcus aureus sequence type 5.

Authors
  • Loftus, R W1
  • Brindeiro, C T2
  • Loftus, C P2
  • Brown, J R3
  • Charnin, J E4
  • Dexter, F5
  • 1 Department of Anaesthesia, University of Iowa, Iowa City, IA, USA. Electronic address: [email protected].
  • 2 RDB Bioinformatics, University of Iowa, Medical Laboratories Building, Iowa City, IA, USA.
  • 3 The Dartmouth Institute, Dartmouth Geisel School of Medicine, NH, USA.
  • 4 Mayo Clinic, Rochester, MN, USA.
  • 5 Department of Anaesthesia, University of Iowa, Iowa City, IA, USA.
Type
Published Article
Journal
The Journal of hospital infection
Publication Date
Jan 01, 2024
Volume
143
Pages
186–194
Identifiers
DOI: 10.1016/j.jhin.2023.07.003
PMID: 37451409
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Staphylococcus aureus sequence type 5 (ST5) is an emerging global threat. To characterize the epidemiology of ST5 transmission in the anaesthesia work area. The retrospective cohort study analysed transmitted, prophylactic antibiotic-resistant Staphylococcus aureus isolates involving anaesthesia work area reservoirs. Using whole-genome analysis, the epidemiology of ST5 transmission was characterized by reservoir(s) of origin, transmission location(s), portal of entry, and mode(s) of transmission. All patients were followed for at least 30 days for surgical site infection (SSI) development. Forty-one percent (18/44; 95% confidence interval: 28-56%) of isolates were ST5. Provider hands were the reservoir of origin for 28% (5/18) of transmitted ST5 vs 4% (1/26) for other STs. Provider hands were the transmission location for 28% (5/18) of ST5 vs 7% (2/26) of other STs. Stopcock contamination occurred for 8% (1/13) of ST5 isolates vs 12% (3/25) of other STs. Sixty-three percent of transmission events occurring between cases on separate operative dates involved ST5. ST5 was more likely to harbour resistance traits (ST5 median (interquartile range) 3 (2-3) vs 2 (1-2) other STs; P < 0.001) and had greater resistance to cefazolin, piperacillin-tazobactam, and/or ciprofloxacin (ST5: 3 (2-3) vs 2 (1-3) other STs; P = 0.02). ST5 was associated with three of six SSIs. ST5 is prevalent among transmitted, prophylactic antibiotic-resistant isolates in the anaesthesia work area. Transmission involves provider hands and one patient to another on future date(s). ST5 is associated with a greater number of resistance traits and reduced in-vitro susceptibility vs other intraoperative meticillin-resistant S. aureus. Copyright © 2023 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

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