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Characterization of viral double-stranded RNA-binding proteins.

Authors
  • Jacobs, B L
  • Langland, J O
  • Brandt, T
Type
Published Article
Journal
Methods (San Diego, Calif.)
Publication Date
Jul 01, 1998
Volume
15
Issue
3
Pages
225–232
Identifiers
PMID: 9735307
Source
Medline
License
Unknown

Abstract

Several viruses have been shown to code for proteins that specifically bind to double-stranded RNA or RNA with large amounts of secondary structure. These proteins have been implicated in providing interferon resistance to viruses and in inhibiting induction of apoptosis by viruses, and have been suggested to be involved in regulation of viral and cellular protein synthesis in infected cells. This article describes methods for detecting and analyzing viral double-stranded RNA-binding proteins.

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