Affordable Access

Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria.

Authors
  • Besra, G S
  • Gurcha, S S
  • Khoo, K H
  • Morris, H R
  • Dell, A
  • Hamid, M E
  • Minnikin, D E
  • Goodfellow, M
  • Brennan, P J
Type
Published Article
Journal
Zentralblatt für Bakteriologie : international journal of medical microbiology
Publication Date
Nov 01, 1994
Volume
281
Issue
4
Pages
415–432
Identifiers
PMID: 7727889
Source
Medline
License
Unknown

Abstract

Representative strains of M. senegalense and an unusual strain, labelled M. farcinogenes (M280) were examined by thin-layer chromatography for the presence of characteristic surface glycolipids. In the case of M. farcinogenes M280 and M. senegalense M264, the glycolipids were of the alkali-labile acyltrehalose lipooligosaccharide (LOS) class of antigens, whereas M. senegalense M263 was found to contain the alkali-stable glycopeptidolipids (GPL). Through a combination of 1H-NMR, methylation analysis, FAB/MS, and other analytical techniques, the structures of these glycolipids were deduced. The LOS glycolipids were found to be similar in structure to the characteristic glucosyltrehalose-based glycolipids isolated previously from clinical isolates of M. fortuitum, but distinct from the diacyltrehaloses characteristic of the type strain of M fortuitum. The glycopeptidolipids from M. senegalense M263 were closely similar to those characterized previously from M.

Report this publication

Statistics

Seen <100 times