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Characterization of reassortant H1-subtype avian influenza viruses isolated from poultry in Zhejiang Province in China from 2013 to 2015

Authors
  • Wu, Haibo1
  • Lu, Rufeng2
  • Peng, Xiuming1
  • Liu, Fumin1
  • Cheng, Linfang1
  • Wu, Nanping1
  • 1 Zhejiang University, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China , Hangzhou (China)
  • 2 The First Affiliated Hospital of Zhejiang Chinese Medical University, Department of Emergency, Hangzhou, 310006, China , Hangzhou (China)
Type
Published Article
Journal
Archives of Virology
Publisher
Springer-Verlag
Publication Date
Jul 20, 2017
Volume
162
Issue
11
Pages
3493–3500
Identifiers
DOI: 10.1007/s00705-017-3487-x
Source
Springer Nature
Keywords
License
Yellow

Abstract

From 2013 to 2015, 32 H1-subtype avian influenza viruses (AIVs), H1N2 (n = 12), H1N3 (n = 14), H1N4 (n = 4) and H1N9 (n = 2), were isolated from poultry in Zhejiang Province in eastern China. These strains were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis of all eight viral genes showed that these strains clustered in the AIV Eurasian lineage. These strains were found to be minimally pathogenic in mice and were able to replicate in mice without prior adaptation. Continued surveillance is needed, considering the important role of poultry in AIV reassortment.

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