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Characterization and pharmacokinetic study of itraconazole solid dispersions prepared by solvent-controlled precipitation and spray-dry methods.

Authors
  • Sim, Taehoon1
  • Lim, Chaemin1
  • Lee, Jun Won1
  • Kim, Dong Wuk2
  • Kim, Youngsam1
  • Kim, Minsoo1
  • Choi, Seungmok1
  • Choi, Han-Gon2
  • Lee, Eun Seong3
  • Kim, Kil-Soo4
  • Kang, Wonku1
  • Oh, Kyung Taek1
  • 1 College of Pharmacy, Chung-Ang University, Seoul, South Korea. , (North Korea)
  • 2 College of Pharmacy, Hanyang University, Gyeonggi-do, South Korea. , (North Korea)
  • 3 Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, South Korea. , (North Korea)
  • 4 College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea. , (North Korea)
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Dec 01, 2017
Volume
69
Issue
12
Pages
1707–1715
Identifiers
DOI: 10.1111/jphp.12805
PMID: 28872678
Source
Medline
Keywords
License
Unknown

Abstract

This study suggests that the SCPM method can be widely used for solid dispersion preparations due to improved dissolution and PK profile.

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