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Characterization of opioid peptides and opioid receptors in the brain of jerboa (Jaculus orientalis), a hibernating rodent.

Authors
  • Bourhim, N
  • Kabine, M
  • Elkebbaj, M S
Type
Published Article
Journal
Brain Research Bulletin
Publisher
Elsevier
Publication Date
Jan 01, 1997
Volume
44
Issue
5
Pages
615–620
Identifiers
PMID: 9365806
Source
Medline
License
Unknown

Abstract

The present study was undertaken to investigate the biochemical characteristics of the opioid receptors and opioid peptides in the jerboa (Jaculus orientalis) brain, a subdesert rodent of Morocco. We have demonstrated the presence of delta, mu, and kappa sites in the jerboa brain. The endogenous opioid peptides methionine-enkephalin, beta-endorphin, and dynorphin were evaluated in different physiological states of the animal (active and hibernating). The circulating methionine-enkephalin in different states of the animal (active, hibernating, exposure to cold conditions, and fasting) was evaluated in the plasma. Our results indicate that the hibernating state the opioid receptors level decreased, whereas the concentration of opioid peptides increased. These findings suggest that both opioid receptors and opioid peptides could be involved in the adaptation of the jerboa to survive under thermal stress.

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