This study received financial support from São Paulo Research Foundation (FAPESP) (grants 2011/18326-4 and 2011/50870-6), and from the Howard Hughes Medical Institute grant 54308198 to GFH. JDL-Jr and GEM received fellowships from FAPESP (2012/04911-5 and 2014/01825-6). DVCO received undergraduate fellowship from National Council for Scientific and Technological Development (CNPq). JM-Jr is supported by a fellowship from Coordination for the Improvement of Higher Education Personnel (CAPES). LAD, AMDS, JCS and SCL are partially supported by Research Fellowship Awards from National Council for Scientific and Technological Development (CNPq). Funding agencies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.