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Characterization of murine T cell activation signals produced by B lymphoma cells.

Authors
  • McKean, D J
  • Nilson, A
  • Beck, B N
  • Mizel, S B
  • Handwerger, B S
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Apr 01, 1985
Volume
134
Issue
4
Pages
2484–2491
Identifiers
PMID: 3871815
Source
Medline
License
Unknown

Abstract

The activation requirements of alloreactive and antigen reactive murine T cells were examined by stimulating class II restricted T cell clones with monoclonal B lymphoma cells. One B lymphoma cell line (T27A) was found to stimulate IL 2 release from some alloreactive T cell clones without stimulating any significant T cell proliferation response. The same B lymphoma cells are capable of stimulating IL 2 release and proliferative responses from other T cell clones. Evidence is presented suggesting that B lymphoma cell stimulation of these T cell clones is largely IL 1 independent and that at least some T cell clones may require activation signals other than Ia, antigen, and IL 1. The addition of exogenous, purified IL 1 to the T cell activation assays was found to have a wide range of stimulatory effects on the proliferative responses of different T cell clones. The absence of comparable IL 1-induced stimulation of IL 2 secretion suggests that IL 1 primarily enhances antigen specific T cell proliferation through mechanisms other than acting as a co-stimulant for IL 2 release.

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