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Characterization of isoquinoline alkaloids from Neolitsea sericea var. aurata by HPLC-SPE-NMR.

Authors
  • Lee, Shoei-Sheng
  • Lai, Yi-Chun
  • Chen, Chien-Kuang
  • Tseng, Li-Hong
  • Wang, Chen-Yu
Type
Published Article
Journal
Journal of natural products
Publication Date
Apr 01, 2007
Volume
70
Issue
4
Pages
637–642
Identifiers
PMID: 17388628
Source
Medline
License
Unknown

Abstract

Application of the HPLC-SPE-NMR technique to identify the alkaloids in an EtOH extract of the leaves of Neolitsea sericea var. aurata led to the characterization of 14 alkaloids while consuming plant material equivalent to 1.1 g. Of these, seven are N-oxides, four of which are new, namely, 9S,17S-pallidine Nalpha-oxide (6), 1S,2S-reticuline Nalpha-oxide (8), 6R,6aS-boldine Nbeta-oxide (9), and 6S,6aS-N-methyllaurotetanine Nalpha-oxide (13). Their structures were also confirmed by partial synthesis.

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