Affordable Access

deepdyve-link
Publisher Website

The characterization of cell line crl-2335 as a Basal-like breast carcinoma model.

Authors
  • Hill Neves, Lori A
  • Ingram, Lishann
  • Davis, Melissa B
Type
Published Article
Journal
Breast cancer : basic and clinical research
Publication Date
Jan 01, 2011
Volume
5
Pages
67–72
Identifiers
DOI: 10.4137/BCBCR.S7087
PMID: 21603256
Source
Medline
Keywords
License
Unknown

Abstract

Basal-like breast cancer has been reported to be the most aggressive and deadly carcinoma sub-type. Patients diagnosed with this subtype have a less than 50% five-year survival. In addition, many studies have reported that this sub-type is more prevalent in specific ethnic groups and is believed to be a key factor that drives certain ethnic disparities in mortality. In order to effectively study this sub-type and determine unique gene expression and biochemical pathways which sustain this cancer's growth, we sought to identify human breast cancer cell lines that represent a model for the basal-like subtype. Here, we report our findings which indicate the African American cell line CRL-2335 is a true representative of basal-like breast carcinoma.

Report this publication

Statistics

Seen <100 times