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Characterization of CD79αcy+ cells in placentas from ruminants.

Authors
  • Cantón, Germán J1
  • Schock, Alex2
  • Melo de Sousa, Noelita3
  • Beckers, Jean-François3
  • Chianini, Francesca4
  • 1 Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, UK; Instituto Nacional de Tecnología Agropecuaria (INTA), EEA Balcarce, B7620EMA, Argentina. , (Argentina)
  • 2 Animal and Plant Health Agency (APHA) Lasswade, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, UK.
  • 3 Physiology of Reproduction, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. , (Belgium)
  • 4 Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, UK. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Veterinary immunology and immunopathology
Publication Date
Nov 01, 2019
Volume
217
Pages
109942–109942
Identifiers
DOI: 10.1016/j.vetimm.2019.109942
PMID: 31569033
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Previous work carried out to characterise different immune cells in ruminant placentas found strong CD79αcy nuclear labelling in cells histologically resembling trophoblast cells. In the attempt to characterize this cell population, placentomes collected from cattle, sheep and water buffaloes were examined by immunohistochemistry with single and double labelling using monoclonal antibodies (mAb) against B lymphocytes and trophoblast cells. Most CD79αcy + cells co-expressed placental lactogen or cytokeratin and were CD21 and MHC class II negative strongly suggesting they do not have a B cell origin. However, a potential immunological role of these cells cannot be ruled out and it is currently unknown if the findings described may have an impact on physiological knowledge, health, and or diseases pathogenesis in ruminants. Copyright © 2019 Elsevier B.V. All rights reserved.

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