Characterization of CD79αcy+ cells in placentas from ruminants.
Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, UK; Instituto Nacional de Tecnología Agropecuaria (INTA), EEA Balcarce, B7620EMA, Argentina.
Animal and Plant Health Agency (APHA) Lasswade, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, UK.
Physiology of Reproduction, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, UK. Electronic address: [email protected]
- Published Article
Veterinary immunology and immunopathology
- Publication Date
Nov 01, 2019
Previous work carried out to characterise different immune cells in ruminant placentas found strong CD79αcy nuclear labelling in cells histologically resembling trophoblast cells. In the attempt to characterize this cell population, placentomes collected from cattle, sheep and water buffaloes were examined by immunohistochemistry with single and double labelling using monoclonal antibodies (mAb) against B lymphocytes and trophoblast cells. Most CD79αcy + cells co-expressed placental lactogen or cytokeratin and were CD21 and MHC class II negative strongly suggesting they do not have a B cell origin. However, a potential immunological role of these cells cannot be ruled out and it is currently unknown if the findings described may have an impact on physiological knowledge, health, and or diseases pathogenesis in ruminants. Copyright © 2019 Elsevier B.V. All rights reserved.
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This record was last updated on 12/31/2019 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/31569033