Affordable Access

Characterization of the adenovirus 2 virion protein, mu.

Authors
  • Anderson, C W
  • Young, M E
  • Flint, S J
Type
Published Article
Journal
Virology
Publication Date
Oct 01, 1989
Volume
172
Issue
2
Pages
506–512
Identifiers
PMID: 2800334
Source
Medline
License
Unknown

Abstract

Adenovirus 2 virions contain a small, highly basic protein known as mu (mu). Partial sequence analysis of mu labeled with radioactive amino acids showed that it is derived from an 11-kDa virion precursor protein, L2-79R. Amino acid analysis, direct microsequence analysis, time-of-flight mass spectrometer analysis, and chemical synthesis demonstrated that mu is the unmodified, 19 amino acid peptide obtained from the 79-residue precursor by adenovirus-encoded proteinase-mediated cleavage after glycine31 and glycine50. Mu bound tightly to DNA and was located in the virion core. In vitro, mu could precipitate DNA fragments, suggesting that it may have a role in viral chromosome condensation.

Report this publication

Statistics

Seen <100 times