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Characteristics of translocation (16;16)(p13;q22) acute myeloid leukemia.

Authors
  • Eghtedar, Alireza
  • Borthakur, Gautam
  • Ravandi, Farhad
  • Jabbour, Elias
  • Cortes, Jorge
  • Pierce, Sherry
  • Kantarjian, Hagop
  • Garcia-Manero, Guillermo
Type
Published Article
Journal
American Journal of Hematology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 01, 2012
Volume
87
Issue
3
Pages
317–318
Identifiers
DOI: 10.1002/ajh.22258
PMID: 22228403
Source
Medline
License
Unknown

Abstract

A subgroup of patients with core binding factor acute myeloid leukemias (AML) is characterized by the presence of the fusion gene CBFb-Myh11. At the cytogenetic level, most of these patients are identified by the presence of an inversion of chromosome 16 [inv(16)(p13q22)] and rarely by a translocation t(16;16)(p13;q22). The aim of this study is to describe the natural history of patients with t(16;16) [N = 6] treated at MD Anderson Cancer Center and compared them with a cohort of patients with inv(16)(p13q22) [n = 61]. In patients with t(16;16) the complete remission rate (CR) was 100% when treated with a combination of fludarabine and high-dose cytarabine. Median overall survival (OS) had not been achieved. There was no difference in response or OS or progression free survival between both groups. Presence of additional chromosomal abnormalities and molecular aberrations had no effect on prognosis. In conclusion, and consistent with previous reports, the natural history of patients with t(16:16)(p13;q22) is similar to that of classic patients with inv16 AML and therefore should be treated similarly.

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