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[The characteristics of the embryotoxic action of kalipsol].

Authors
  • Bandazhevskiĭ, Iu I
  • Shimanovich, A I
Type
Published Article
Journal
Farmakologiia i toksikologiia
Publication Date
Jan 01, 1991
Volume
54
Issue
5
Pages
58–59
Identifiers
PMID: 1800154
Source
Medline
License
Unknown

Abstract

The effect of calipsol on the course of pregnancy and the embryonal development in albino rats was studied. It was found that single injections of the drug in a dose of 200 mg/kg on the 7th or 8th day of pregnancy induced no disorders in the pregnancy course and the embryonal development. At the administration in a dose of 40.0 mg/kg on the 11th, 13th, 15th days of pregnancy calipsol was shown to exert a marked embryolethal action and at the administration on the 7th, 9th, 11th days of pregnancy in doses of 20 and 40 mg/kg increased the number of fetuses with hemorrhages into the internal organs.

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