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Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients.

Authors
  • Lee, Kyoung Hwa1
  • Yoo, Seul Gi1
  • Cho, Yonggeun2
  • Kwon, Da Eun1
  • La, Yeonju1
  • Han, Sang Hoon3
  • Kim, Myoung Soo4
  • Choi, Jin Sub4
  • Kim, Soon Il4
  • Kim, Yu Seun4
  • Min, Yoo Hong5
  • Cheong, June-Won5
  • Kim, Jin Seok5
  • Song, Yong Goo1
  • 1 Division of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 2 Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 3 Division of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: [email protected] , (North Korea)
  • 4 Department of Transplantation Surgery and Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 5 Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. , (North Korea)
Type
Published Article
Journal
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Publication Date
Apr 01, 2021
Volume
54
Issue
2
Pages
253–260
Identifiers
DOI: 10.1016/j.jmii.2019.05.007
PMID: 31262511
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Transplant recipients are vulnerable to life-threatening community-acquired respiratory viruses (CA-RVs) infection (CA-RVI). Even if non-transplant critically ill patients in intensive care unit (ICU) have serious CA-RVI, comparison between these groups remains unclear. We aimed to evaluate clinical characteristics and mortality of CA-RVI except seasonal influenza A/B in transplant recipients and non-transplant critically ill patients in ICU. We collected 37,777 CA-RVs multiplex real-time reverse transcription-polymerase chain reaction test results of individuals aged ≥18 years from November 2012 to November 2017. The CA-RVs tests included adenovirus, coronavirus 229E/NL63/OC43, human bocavirus, human metapneumovirus, parainfluenza virus 1/2/3, rhinovirus, and respiratory syncytial virus A/B. We found 286 CA-RVI cases, including 85 solid organ transplantation recipients (G1), 61 hematopoietic stem cell transplantation recipients (G2), and 140 non-transplant critically ill patients in ICU (G3), excluding those with repeated isolation within 30 days. Adenovirus positive rate and infection cases were most prominent in G2 (p < 0.001). The median time interval between transplantation and CA-RVI was 30 and 20 months in G1 and G2, respectively. All-cause in-hospital mortality was significantly higher in G3 than in G1 or G2 (51.4% vs. 28.2% or 39.3%, p = 0.002, respectively). The mechanical ventilation (MV) was the independent risk factor associated with all-cause in-hospital mortality in all three groups (hazard ratio, 3.37, 95% confidence interval, 2.04-5.56, p < 0.001). This study highlights the importance of CA-RVs diagnosis in transplant recipients even in long-term posttransplant period, and in non-transplant critically ill patients in ICU with MV. Copyright © 2019. Published by Elsevier B.V.

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