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[Characteristics of bFGF and TGF-beta expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair].

Authors
  • Fu, X B
  • Sun, T Z
  • Yang, Y H
Type
Published Article
Journal
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Publication Date
Sep 01, 2000
Volume
14
Issue
5
Pages
271–274
Identifiers
PMID: 12516473
Source
Medline
License
Unknown

Abstract

The different distribution of bFGF and TGF-beta in dermal chronic ulcer and hypertrophic scar may be the reason of different results of tissue repair. The pathogenesis of wound healing delay in a condition of high concentration of growth factors may come from the binding disorder of growth factors and their receptors. bFGF may be involved in all process of formation of hypertrophic scar, but TGF-beta may only play roles in the early stage.

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