Affordable Access

deepdyve-link
Publisher Website

Characteristic Comparison of an Intraoral Thin Film Containing Astaxanthin Nanoemulsion Using Sodium Alginate and Gelatin Polymers

Authors
  • NURDIANTI, Lusi1, 2
  • RUSDIANA, Taofik1
  • SOPYAN, Iyan1
  • PUTRIANA, Norisca Aliza1
  • AIMAN, Hanifa Rifdah1
  • FAJRIA, Tengku Ruhul1
  • 1 Padjadjaran University Bandung Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Jawa Barat, Indonesia
  • 2 Bakti Tunas Husada Institute of Health Science, Pharmacy Department, Tasikmalaya, Indonesia
Type
Published Article
Journal
Turkish Journal of Pharmaceutical Sciences
Publisher
Galenos Publishing
Publication Date
Jun 18, 2021
Volume
18
Issue
3
Pages
289–295
Identifiers
DOI: 10.4274/tjps.galenos.2020.25483
PMID: 34157818
PMCID: PMC8231319
Source
PubMed Central
Keywords
Disciplines
  • Original Article
License
Unknown

Abstract

Objectives: The present study was conducted to compare the characteristics of a thin film containing an astaxanthin-loaded nanoemulsion (TFANE) using two kinds of natural polymers, namely sodium alginate and gelatin. Materials and Methods: An astaxanthin nanoemulsion was prepared by using the self-nanoemulsifying method, followed by incorporation into a polymer matrix system by the solvent casting method to form TFANE. A characteristic comparison between the sodium alginate and gelatin matrix systems was carried out by comparing the physical and mechanical film properties. At the end of the study, in vitro dissolution tests were also assessed. Results: An intraoral film with good physical and mechanical properties containing an astaxanthin-loaded nanoemulsion was developed successfully using a natural polymer matrix system. The film, made from a gelatin matrix system containing an astaxanthin nanoemulsion, was more flexible and harder than films made from a sodium alginate matrix system, where all of the films have ideal characteristics for intraoral delivery. The dissolution test results showed that, with both sodium alginate and gelatin, more than 90% of the drug was released at 15 minutes. Conclusion: Gelatin as a natural polymer appears to be promising for the preparation of an intraoral thin film delivery system.

Report this publication

Statistics

Seen <100 times