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Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array.

Authors
  • Broutin, Sophie
  • Commo, Frédéric
  • De Koning, Leanne
  • Marty-Prouvost, Bérengère
  • Lacroix, Ludovic
  • Talbot, Monique
  • Caillou, Bernard
  • Dubois, Thierry
  • Ryan, Anderson J
  • Dupuy, Corinne
  • Schlumberger, Martin
  • Bidart, Jean-Michel
Type
Published Article
Journal
Thyroid
Publisher
Mary Ann Liebert
Publication Date
Jan 01, 2014
Volume
24
Issue
1
Pages
43–51
Identifiers
DOI: 10.1089/thy.2013.0514
PMID: 24256343
Source
Medline
License
Unknown

Abstract

Overall, our results confirmed the interest of RPPA for screening global changes induced in signaling pathways by kinase inhibitors. MAPK and AKT were identified as the main pathways involved in vandetanib response in MTC models. Our results also suggest alternative routes for controlling the disease, and provide a rationale for the development of therapeutic combinations based on the comprehensive identification of molecular events induced by inhibitors.

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