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Changes of the serum antibiotic levels during open heart surgery (ceftazidim, ciprofloxacin, clindamycin).

Authors
Type
Published Article
Journal
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové
Publication Date
Volume
43
Issue
1
Pages
23–27
Identifiers
PMID: 10934782
Source
Medline
License
Unknown

Abstract

CPB can modify the time course of antibiotic serum concentrations. The serum levels of CTZ at the end of the longest procedures were found to be below the MICs for some of the suspected pathogens. We recommend to use higher antibiotic doses for prophylaxis and to administer the second dose with protamin sulphate to obtain maximum concentration in newly formed blood clots.

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