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Changes in serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from adult patients in Asia: Emergence of drug-resistant non-vaccine serotypes.

Authors
  • Kim, So Hyun1
  • Chung, Doo Ryeon1
  • Song, Jae-Hoon2
  • Baek, Jin Yang1
  • Thamlikitkul, Visanu3
  • Wang, Hui4
  • Carlos, Celia5
  • Ahmad, Norazah6
  • Arushothy, Revathy6
  • Tan, Si Huei7
  • Lye, David8
  • Kang, Cheol-In9
  • Ko, Kwan Soo10
  • Peck, Kyong Ran9
  • 1 Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, South Korea; Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. , (North Korea)
  • 2 Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, South Korea. Electronic address: [email protected] , (North Korea)
  • 3 Faculty of Medicine Siriraj Hospital, Bangkok, Thailand. , (Thailand)
  • 4 Peking University People's Hospital, Beijing, China. , (China)
  • 5 Research Institute for Tropical Medicine, Manila, Philippines. , (Philippines)
  • 6 Institute for Medical Research, Kuala Lumpur, Malaysia. , (Malaysia)
  • 7 Changi General Hospital, Singapore. , (Singapore)
  • 8 Tan Tock Seng Hospital, Singapore. , (Singapore)
  • 9 Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. , (North Korea)
  • 10 Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, South Korea; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea. , (North Korea)
Type
Published Article
Journal
Vaccine
Publication Date
Aug 27, 2020
Volume
38
Issue
38
Pages
6065–6073
Identifiers
DOI: 10.1016/j.vaccine.2019.09.065
PMID: 31590932
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This study was performed to investigate the serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in Asian countries. A prospective surveillance study on S. pneumoniae collected from adult patients (≥50 years old) with invasive pneumococcal disease or community-acquired pneumonia was performed at 66 hospitals in Asian countries (Korea, China, Malaysia, Singapore, the Philippines, and Thailand) in 2012-2017. Serotyping and antimicrobial susceptibility tests of 850 pneumococcal isolates were performed. The proportions of isolates with serotypes covered by 13-valent pneumococcal conjugate vaccine (PCV13) were 37.0% in Korea, 53.4% in China, 77.2% in Malaysia, 35.9% in the Philippines, 68.7% in Singapore, and 60.2% in Thailand. Major serotypes were 19F (10.4%), 19A (10.1%), and 3 (8.5%) in 2012-2017, with different serotype distributions in each country. Macrolide resistance in pneumococci was high (66.8%) and prevalence of multidrug resistance (MDR) also remained high (50.8%). MDR non-PCV13 serotypes such as 11A, 15A, 35B, and 23A have emerged in Asian countries. This study showed the persistent prevalence of 19F and 19A with a noteworthy increase of certain non-PCV13 serotypes in Asian countries. High prevalence of macrolide resistance and MDR was also found in pneumococcal isolates. These data emphasize the need for continued surveillance of pneumococcal epidemiology in Asia in the post-pneumococcal vaccine era. Copyright © 2019 Elsevier Ltd. All rights reserved.

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