This study deals with the analysis of changes in the secondary landscape structure of the territory of the Jeseniky Mountains (Czech Republic) monitored in the years 1946, 1953, 1962, 2000, and 2016. The study analysed georeferencing aerial geodetic images in the QGIS 2.18 program. On the basis of the land use classification key that was created, historical changes were identified in the following categories of land use; forest, arable land, orchards, water surfaces, wild life refuges and scattered greenery, river networks, permanent grass stands, meadows and pastures, gardens and built-up areas, courtyards and hard surfaces. The surface areas of land use categories were utilized for the calculation of change indicators regarding the structure of the landscape (landscape similarity index, coefficient of ecological stability, and change index). The maps for land use created for individual historical periods functioned as the starting point for a comprehensive assessment of the landscape by means of a SWOT analysis, which created the basis for a proposal for permanently sustainable utilization of the landscape in the area that was monitored. The study results indicate that the analysis of the historical development of the secondary landscape structure may be utilized as a decision support tool when planning sustainable landscape management.