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Changes in plasma catecholamines and pulsatile patterns of gonadotropin release in subjects with a normal ovulatory cycle and with polycystic ovary syndrome.

Authors
  • Yoshino, K
  • Takahashi, K
  • Shirai, T
  • Nishigaki, A
  • Araki, Y
  • Kitao, M
Type
Published Article
Journal
International journal of fertility
Publication Date
Jan 01, 1990
Volume
35
Issue
1
Pages
34–39
Identifiers
PMID: 1968442
Source
Medline
License
Unknown

Abstract

Plasma LH levels in women and female laboratory animals fluctuate. Since catecholamines play a role in gonadotropin secretion, we investigated the possible correlation between catecholamine metabolites and pulsatile patterns of gonadotropin release by measuring two catecholamine metabolites, MHPG and DOPAC. LH levels had a pulsatile pattern, and the levels of MHPG fluctuated. The average of LH and MHPG in polycystic ovary syndrome was significantly higher than that of a normal ovulatory cycle, and the average fluctuation of LH and MHPG in polycystic ovary syndrome was also significantly greater than that in a normal ovulatory cycle. There may be a correlation between the pulsatile pattern of gonadotropin and catecholamine activity, particularly adrenergic activity. It is suspected that adrenergic activity may correlate with the pulsatile pattern in polycystic ovary syndrome.

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