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[Changes in lipid spectrum in rats with chronic heart failure of different severity on the background of angiotensin-converting enzyme inhibitors and beta-adrenoblockers].

Authors
  • Sidorov, A V
  • Fateev, M M
Type
Published Article
Journal
Zhurnal evoliutsionnoĭ biokhimii i fiziologii
Publication Date
Jan 01, 2013
Volume
49
Issue
4
Pages
272–277
Identifiers
PMID: 24459860
Source
Medline
License
Unknown

Abstract

The character of lipid spectrum changes in rats with experimental heart failure of non-ischemic genesis depended on its severity. In mild heart failure there was found an increase in the low density lipoprotein levels, whereas in the severe one--a decrease of total cholesterol levels at the expense of the low density lipoproteins. The ACE inhibitors produced no significant changes in the lipid spectrum. The effect of beta-adrenoblockers was determined by their selectivity for beta1-adrenoreceptors. The most selective drugs were distinguished by the metabolically neutral activity. On the contrary, nonselective beta-adrenoblockers increased the degree of plasma atherogeneity.

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