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Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and females.

Authors
  • Moran, Antoinette
  • Jacobs, David R Jr
  • Steinberger, Julia
  • Steffen, Lyn M
  • Pankow, James S
  • Hong, Ching-Ping
  • Sinaiko, Alan R
Type
Published Article
Journal
Circulation
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
May 06, 2008
Volume
117
Issue
18
Pages
2361–2368
Identifiers
DOI: 10.1161/CIRCULATIONAHA.107.704569
PMID: 18427135
Source
Medline
License
Unknown

Abstract

During the transition from late childhood through adolescence, insulin resistance in males increased in association with increased triglycerides and decreased high-density lipoprotein cholesterol, despite a concurrent reduction in body fatness, whereas the opposite occurred in females. These gender-related developmental changes in insulin resistance, which were independent from changes in fatness, total cholesterol, and low-density lipoprotein cholesterol, are consistent with an early role for insulin resistance in the increased cardiovascular risk found in males.

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