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Changes in brain gene expression shared by scrapie and Alzheimer disease.

Authors
  • J R Duguid
  • C W Bohmont
  • N G Liu
  • W W Tourtellotte
Publication Date
Sep 01, 1989
Source
PMC
Keywords
Disciplines
  • Biology
  • Medicine
License
Unknown

Abstract

We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.

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