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Changes in haemoglobin oxygen affinity and erythrocytic 2,3-BPG in ethanol-treated rats.

Authors
Type
Published Article
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
21
Issue
3
Pages
291–293
Identifiers
PMID: 2341014
Source
Medline
License
Unknown

Abstract

1. The effects of alcohol on blood oxygen transport properties were studied in rats after a chronic administration of ethanol in drinking water. 2. Ingestion of ethanol provokes an increase in haemoglobin oxygen affinity (at pH 7.4). This is caused by a drop in the MCHC and erythrocyte 2,3-BPG concentration that give rise to a decrease in the 2,3-BPG/Hb ratio. 3. No changes in haemoglobin fractions were observed. 4. The results indicate a depletion in the red blood cell glycolytic pathways. 5. If metabolic acidosis occurs, the expected loss of blood affinity in vivo due to the fall in pH would be compensated by the changes observed in vitro.

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