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Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey.

Authors
  • Xiao, Zhuang-wei
  • Cao, Chu-yu
  • Wang, Zhao-xin
  • Li, Jun-xiong
  • Liao, Hai-yong
  • Zhang, Xue-xin
Type
Published Article
Journal
Chinese medical journal
Publication Date
Nov 05, 2006
Volume
119
Issue
21
Pages
1802–1807
Identifiers
PMID: 17097035
Source
Medline
License
Unknown

Abstract

In rhesus monkey, acute morphine injection has both rapid and lasting effects on DAT by downregulating its function. The decline was partially reversible following morphine abstinence. The results suggest that striatum is one effective target of morphine and that the DAT function in striatum is one indicator for morphine addiction.

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