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Changes in Cytokines and Aggrecan ARGS Neoepitope in Synovial Fluid and Serum and in C-Terminal Crosslinking Telopeptide of Type II Collagen and N-Terminal Crosslinking Telopeptide of Type I Collagen in Urine Over Five Years After Anterior Cruciate Ligament Rupture: An Exploratory Analysis in the Knee Anterior Cruciate Ligament, Nonsurgical Versus Surgical Treatment Trial.

Authors
  • Struglics, André
  • Larsson, Staffan
  • Kumahashi, Nobuyuki
  • Frobell, Richard
  • Lohmander, L Stefan
Type
Published Article
Journal
Arthritis & rheumatology (Hoboken, N.J.)
Publication Date
Jul 01, 2015
Volume
67
Issue
7
Pages
1816–1825
Identifiers
DOI: 10.1002/art.39146
PMID: 25914389
Source
Medline
License
Unknown

Abstract

Acute ACL injury induced highly increased levels of inflammatory cytokines in the joint, and these were associated with proteolysis of aggrecan and type II collagen. Cytokine levels remained increased up to 5 years after injury, indicative of extended local inflammation in the joint.

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