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Changes in the concentration and composition of plasma lipoproteins during the acute phase response.

Authors
  • Carpentier, Yvon A
  • Scruel, Olivier
Type
Published Article
Journal
Current Opinion in Clinical Nutrition & Metabolic Care
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2002
Volume
5
Issue
2
Pages
153–158
Identifiers
PMID: 11844981
Source
Medline
License
Unknown

Abstract

The acute phase reactions, associated with injury, inflammation, or sepsis, markedly affect the concentration and composition of plasma lipids and lipoproteins. Hepatic production of triglycerides and very low density lipoprotein formation are increased, but do not necessarily result in high plasma triglyceride levels. In contrast, all conditions lower plasma cholesterol by decreasing its content in both low-density and high-density lipoproteins. In addition, substantial changes in protein and lipid composition of lipoproteins are observed that may redefine the function of these particles, but also increase their atherogenic and inflammatory properties.

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