Affordable Access

Changes in cochlear microphonic and neural sensitivity produced by acoustic trauma.

Authors
  • Patuzzi, R B
  • Yates, G K
  • Johnstone, B M
Type
Published Article
Journal
Hearing Research
Publisher
Elsevier BV
Publication Date
May 01, 1989
Volume
39
Issue
1-2
Pages
189–202
Identifiers
PMID: 2737965
Source
Medline
License
Unknown

Abstract

The low-frequency (200 Hz) microphonic potentials at the round window and in the organ of Corti of the first turn of the guinea pig cochlea have been measured before and after acoustic overstimulation. Reductions in the amplitude of this microphonic after loud sound are highly correlated with neural threshold elevation in this region. The fall in the microphonic amplitude appears due to an inactivation of mechano-electrical transduction channels at the apex of the outer hair cells into a closed state. These results are consistent with the idea that the current through the outer hair cells controls the mechanical sensitivity of the organ of Corti, and that the temporary loss of mechanical and neural sensitivity following loud sound is due to a simple inactivation of the mechano-electrical transduction channels.

Report this publication

Statistics

Seen <100 times