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Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared.

Authors
  • Hrabovsky, Vladimir1
  • Blaha, Vladimir2
  • Hyspler, Radomir2
  • Ticha, Alena2
  • Skrobankova, Martina1
  • Svagera, Zdenek3
  • 1 Intensive Care Unit, Department of Internal Medicine, University Hospital Ostrava, Czech Republic. , (Czechia)
  • 2 Department of Metabolic Care and Gerontology, University Hospital Hradec Kralove, Czech Republic. , (Czechia)
  • 3 Department of Clinical Biochemistry, University Hospital Ostrava, Czech Republic. , (Czechia)
Type
Published Article
Journal
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
Publication Date
Sep 01, 2019
Volume
163
Issue
3
Pages
253–258
Identifiers
DOI: 10.5507/bp.2018.055
PMID: 30238936
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cholesterol is derived via de novo synthesis and dietary absorption. Both processes can be monitored by determination of non-cholesterol sterol concentrations (lathosterol for synthesis; sitosterol and campesterol for absorption). The hypocholesterolemia that occurs during acute illness is a result of a multifactorial inability to compensate for the increased needs for this metabolite. The aim of this study was to examine the plasma cholesterol profile and both processes of cholesterol acquisition during acute upper gastrointestinal haemorrhage with emphasis on liver cirrhosis. Thirty five patients with acute upper gastrointestinal bleeding (cirrhosis n=14, non-cirrhosis n=21) were evaluated over a 6 day period. The control cohort consisted of 100 blood donors. Serum concentrations of total, LDL (low-density lipoprotein) and HDL (high-density lipoprotein) cholesterol were measured enzymatically. Sterol concentrations were analysed using gas chromatography, data were statistically analysed. In all patients, we found lower plasma levels of total cholesterol (P Conclusion: Our results showed substantial abnormalities in the cholesterol plasma profile including both the processes of cholesterol acquisition in patients with upper acute gastrointestinal bleeding. The patients with or without liver cirrhosis had similar trends in cholesterol plasma levels. Depression of cholesterol synthesis was, however, prolonged in the cirrhotic group and the data also suggest a different phytosterol metabolism.

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