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Changes in bone biological markers after treatment of Iranian diabetic patients with pioglitazone: No relation to polymorphism of PPAR-γ (Pro12Ala).

Authors
  • Namvaran, Fatemeh
  • Rahimi-Moghaddam, Parvaneh
  • Azarpira, Negar
  • Dabbaghmanesh, Mohammad Hossien
  • Bakhshayeshkaram, Marzieh
  • Namvaran, Mohamad Mahdi
Type
Published Article
Journal
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
Publication Date
Apr 01, 2013
Volume
18
Issue
4
Pages
277–282
Identifiers
PMID: 24124423
Source
Medline
Keywords
License
Unknown

Abstract

Our findings did not reveal a significant association between this polymorphism and bone turnover markers after pioglitazone treatment. The reduced insulin resistance might be the reason that CTx values decreased and osteocalcin increased significantly after short-term pioglitazone treatment. These findings suggest the need for further studies on the possible role of insulin in regulation of bone metabolism.

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