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Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children.

Authors
  • Al-Mashhadi, Ammar1
  • Checa, Antonio2
  • Wåhlin, Nils3, 4
  • Neveus, Tryggve5
  • Fossum, Magdalena3, 4
  • Wheelock, Craig E2
  • Karanikas, Birgitta1
  • Stenberg, Arne1
  • Persson, A Erik G6, 7
  • Carlstrom, Mattias8
  • 1 Pediatric Surgery Section, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. , (Sweden)
  • 2 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 3 Department of Women's and Children's Health, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 4 Department of Pediatric Surgery, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. , (Sweden)
  • 5 Pediatric Nephrology Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. , (Sweden)
  • 6 Department Medical Cell Biology, Uppsala University, Uppsala, Sweden. , (Sweden)
  • 7 Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz Väg 2, 17177, Stockholm, Sweden. , (Sweden)
  • 8 Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz Väg 2, 17177, Stockholm, Sweden. [email protected] , (Sweden)
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Apr 01, 2018
Volume
33
Issue
4
Pages
639–649
Identifiers
DOI: 10.1007/s00467-017-3848-4
PMID: 29196979
Source
Medline
Keywords
License
Unknown

Abstract

This study demonstrates increased arterial pressure and oxidative stress in children with hydronephrosis compared with healthy controls, which can be restored to normal levels by surgical correction of the obstruction. Once reference data on ambulatory blood pressure in this young age group become available, we hope cut-off values can be defined for deciding whether or not to correct hydronephrosis surgically.

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