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Changed responsiveness of the detrusor in rabbits with alloxan induced hyperglycemia: possible role of 5-hydroxytryptamine for diabetic bladder dysfunction.

Authors
  • Ichiyanagi, Nobutaka
  • Tsujii, Toshihiko
  • Masuda, Hitoshi
  • Kihara, Kazunori
  • Goto, Moritaka
  • Azuma, Hiroshi
Type
Published Article
Journal
The Journal of Urology
Publisher
Elsevier
Publication Date
Jul 01, 2002
Volume
168
Issue
1
Pages
303–307
Identifiers
PMID: 12050561
Source
Medline
License
Unknown

Abstract

The decrease in neurogenic bladder contraction possibly accompanied by the decreased density of muscarinic receptors, the potentiation of neurogenic bladder contraction with 5-hydroxytryptamine probably due to facilitated cholinergic transmission and the enhanced contractility to 5-hydroxytryptamine would be at least in part involved in bladder dysfunction associated with hyperglycemia.

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