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[Change in the oxidative metabolism of macrophages during transformation into foam cells].

Authors
  • Zenkov, N K
  • Dushkin, M I
  • Liubimov, G Iu
  • Men'shchikova, E B
Type
Published Article
Journal
Voprosy medit︠s︡inskoĭ khimii
Publication Date
Jan 01, 1994
Volume
40
Issue
1
Pages
2–4
Identifiers
PMID: 8122402
Source
Medline
License
Unknown

Abstract

Oxidative metabolism of murine peritoneal macrophages was studied after cultivation in a mixture containing acetylated low density lipoproteins within 24 and 48 hr using luminol- and lucigenin-dependent chemiluminescence. Chemiluminescence of foamy cells, induced by opsonized zymosan, was not distinctly altered as compared with native macrophages; at the same time, the rate of both lucigenin- and luminol-dependent spontaneous chemiluminescence was distinctly decreased. The imbalance of the oxidative reactions observed enables the authors to propose the antioxidative mechanism of atherosclerotic lesion.

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