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Challenges and opportunities in dermal/transdermal delivery.

Authors
  • Paudel, Kalpana S1
  • Milewski, Mikolaj
  • Swadley, Courtney L
  • Brogden, Nicole K
  • Ghosh, Priyanka
  • Stinchcomb, Audra L
  • 1 College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA.
Type
Published Article
Journal
Therapeutic delivery
Publication Date
Jul 01, 2010
Volume
1
Issue
1
Pages
109–131
Identifiers
PMID: 21132122
Source
Medline
License
Unknown

Abstract

Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs. Further advances in transdermal delivery depend on the ability to overcome the challenges faced regarding the permeation and skin irritation of the drug molecules. Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications. As evident from the ongoing clinical trials of a wide variety of drugs for various clinical conditions, there is a great future for transdermal delivery of drugs.

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