Affordable Access

The challenge for the next generation of feline calicivirus vaccines.

Authors
  • Radford, Alan D
  • Dawson, Susan
  • Coyne, Karen P
  • Porter, Carol J
  • Gaskell, Rosalind M
Type
Published Article
Journal
Veterinary Microbiology
Publisher
Elsevier
Publication Date
Oct 05, 2006
Volume
117
Issue
1
Pages
14–18
Identifiers
PMID: 16698199
Source
Medline
License
Unknown

Abstract

Feline calicivirus (FCV) has been shown to evolve within individual cats and in the environment of colonies. This evolution and the diversity it creates has important clinical implications, not only for the disease in cats, but also for attempts to control disease by vaccination. Generally speaking, existing vaccines appear to be very effective at controlling the majority of clinical disease. However, some concerns remain including a failure to induce sterilising immunity, occasional vaccine breakdowns, and for live vaccines, occasional vaccine-induced disease. Key areas for future vaccine development include monitoring and broadening the cross-reactivity of vaccine immunity to field viruses, especially the recently evolved highly virulent strains, and attempting to reduce/eliminate field virus shedding by vaccinated cats.

Report this publication

Statistics

Seen <100 times