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The challenge to define the optimal prophylactic regimen for vitamin K deficiency bleeding in infants.

Authors
  • Lembo, Chiara1
  • Buonocore, Giuseppe1
  • Perrone, Serafina2
  • 1 Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. , (Italy)
  • 2 Department of Medicine and Surgery, University of Parma, Parma, Italy. , (Italy)
Type
Published Article
Journal
Acta Paediatrica
Publisher
Wiley (Blackwell Publishing)
Publication Date
Apr 01, 2021
Volume
110
Issue
4
Pages
1113–1118
Identifiers
DOI: 10.1111/apa.15566
PMID: 32892390
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Infants are at risk of vitamin K deficiency that may lead to vitamin K deficiency bleeding (VKDB). Although many vitamin K prophylactic regimens have been developed throughout the years, still cases of late form VKBD may occur. The introduction of combined prophylactic strategy with prolonged oral prophylaxes after the intramuscular dose at birth has showed a decrease of the late severe VKDB incidence. Nevertheless, there is still lack of consensus about the administration scheme after the first dose at birth. CONCLUSION: Late form VKBD is not eradicated, and the best prophylactic regimen in term and preterm infants is still an open debate. © 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

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