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Chai-ling-tang (Japanese name: sairei-to) as an oral adjuvant.

Authors
  • Egawa, Y1
  • Suzuki, I
  • Nagi, N
  • Yadomae, T
  • Kawakita, T
  • Kikuchi, S
  • Nomoto, K
  • 1 Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy, Japan. , (Japan)
Type
Published Article
Journal
International Journal of Immunopharmacology
Publisher
Elsevier
Publication Date
Jan 01, 1991
Volume
13
Issue
7
Pages
1031–1036
Identifiers
PMID: 1761348
Source
Medline
License
Unknown

Abstract

Immunomodulating and anti-tumor activities of orally administered Chai-Ling-Tang (Japanese name: sairei-to, ST) were investigated. The oral administration of ST into mice augmented the antibody response to intraperitoneally administered 2, 4, 6-trinitrophenyl-haptenated sheep red blood cells (TNP-SRBC). Orally administered ST showed also an enhancing effect on the antibody response to TNP-SRBC administered by the oral route. In addition, orally administered ST markedly activated the peritoneal macrophages to enhanced phagocytic and lysosomal enzyme activities. A significant inhibition of tumor growth was observed in a syngeneic tumor-mouse system when ST was administered orally. These results suggest that ST has an efficiency as an oral adjuvant or an oral biological response modifier (BRM).

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